Biopharmaceutical and rheometric studies in the development of a gel composition with dimethindene maleate

Every year there is an increase in the number of cases hypersensitivity to bites from various insects. A local allergic reaction occurs within a few minutes and accompanied by acute pain at site bite, severe itching, hyperemia, appearance papules, tissue edema, sometimes small-point rash around. Considering small drugs for therapy manifestations unidirectional nature their action, it urgent develop drug containing antihistamine dimethindene maleate dexpanthenol, which plays role anti-inflammatory, reparative dermatoprotective substance.
 The aim. aim study substantiate delivery system dexpanthenol based on biopharmaceutical rheometric research methods.
 Materials methods. To determine component composition active ingredient system, type dimetindene administration was substantiated studying its solubility. As pharmaceutical ingredients, hydrogels were considered, made using high-molecular compounds origins: natural substance – xanthan gum, semi-synthetic gyroxypropyl methylcellulose, synthetic carbomer. rate release estimated kinetics through semipermeable membrane. assessment viscoelastic properties carried out performing oscillatory rheometry test, makes possible quantitatively viscous elastic components, as well characterize bioadhesive properties.
 Results. Based results solubility hydrophilic non-aqueous solvents, determined that propylene glycol optimal ensuring introduction into hydrogel bases solution. result hydrogels, found use carbomer provides 28.33 % maleate, gum 25 %, hydroxypropyl methylcellulose 7.33 %. When determining values ​​of storage modulus G', loss G" damping (attenuation) factor tg δ, carbomer-based solid, methylcellulose-based are liquid. Bioadhesion surface skin during has advantage hydrogel.
 Conclusions. combination methods substantiating rational further pharmacological microbiological studies